Recombinant RELN protein (His tag)

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Recombinant Reelin (EC 3.4.21.-) Fragment (aa 1254-1400) is a 147-amino acid human-derived protein fragment designed for structural and biochemical studies. This soluble, stable unit enables focused investigation of Reelin's extracellular matrix serine protease functions in neuronal development and migration.

Reelin, encoded by the RELN gene in Homo sapiens, is an extracellular matrix serine protease secreted by pioneer neurons that critically regulates neuronal layering in the cerebral cortex and cerebellum during neurodevelopment. It coordinates cell positioning through modulation of microtubule function and neuronal migration. Reelin's binding to lipoprotein receptors VLDLR and LRP8/APOER2 triggers tyrosine phosphorylation of DAB1 and influences TAU phosphorylation. Additionally, it acts as a migration barrier for sympathetic preganglionic neurons in the spinal cord, with its enzymatic activity contributing to cell adhesion modulation. As a secreted protein localized to the extracellular space and matrix, Reelin plays a fundamental role in central nervous system development and organization.