Recombinant RECO protein (His tag)

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Recombinant Human Recoverin (RCVRN) Fragment (aa 2-200) is a high-purity protein designed for studying calcium-sensing and phototransduction mechanisms in photoreceptor cells. This fragment encompasses all four EF-hand domains, making it an ideal tool for investigating calcium-dependent regulation and signal modulation in vision research.

Recoverin (Cancer-associated retinopathy protein) functions as a calcium sensor that regulates phototransduction in both cone and rod photoreceptor cells. It modulates light sensitivity under dark and dim conditions by prolonging rhodopsin activation through inhibition of GRK1-mediated phosphorylation. The protein enhances scotopic vision by improving signal transfer between rod photoreceptors and rod bipolar cells, and facilitates detection of motion in bright light. Recoverin localizes primarily to photoreceptor inner segments, with approximately 10% translocating to outer segments upon light stimulation in a calcium-dependent manner. Its myristoylated form targets to rod photoreceptor outer membranes, where it plays crucial roles in visual adaptation and sensitivity.