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Product Name
Cynomolgus HER2/ErbB2 (Fc Tag) recombinant protein
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Description
Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
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Protein name
Receptor protein-tyrosine kinase
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Protein short names
HER2; NGL; MKIAA3023; CD340; HER-2/NEU; ERBB-2; TKR1; C-ERBB2; MLN19; C-ERBB-2; C-NEU; HER-2; RP23-355L10.8; ERBB2; NEU
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Uniprot ID
G7PUM4
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Gene Name
EGM_07851
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the cynomolgus ERBB2 (Met1-Thr652) [ Rhesus ERBB2 (XP_001090430.1,Asp121Asn,Leu122Pro); similar to Macaca fascicularis ERBB2 (EHH58073.1)], was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Cynomolgus
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Molecular weight
The recombinant cynomolgus ERBB2 consists 871 amino acids and predicts a molecular mass of 96.4 kDa.
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Purity
> 85 % as determined by SDS-PAGE.
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Validations
Cynomolgus HER2 / ErbB2 Protein (Fc Tag) SDS-PAGE
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