Recombinant RCC1 protein (His tag)

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Recombinant Regulator of Chromosome Condensation (RCC1) Fragment (aa 2-421) from Homo sapiens, a stable and soluble protein unit ideal for studying RAN-mediated nuclear import, mitotic spindle assembly, and chromosome condensation dynamics.

RCC1 is a critical guanine-nucleotide exchange factor that promotes the exchange of Ran-bound GDP for GTP, playing a pivotal role in RAN-mediated nuclear import and mitotic processes. It contributes to generating high levels of chromosome-associated GTP-bound RAN, essential for mitotic spindle assembly and proper progression through mitosis. Additionally, RCC1 maintains nuclear Ran-GTP levels to facilitate cargo release from importins after nuclear import and regulates the onset of chromosome condensation during the S phase. The protein binds to nucleosomes and double-stranded DNA and is predominantly localized in the nucleus during interphase, with association to mitotic chromosomes and presence in the cytoplasm, underscoring its multifaceted role in cell cycle regulation and chromosomal dynamics.