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RBP4 antibody

Cat.#: 107502

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Product Information

  • Product Name
    RBP4 antibody
  • Documents
  • Description
    RBP4 Mouse Monoclonal antibody. Positive WB detected in Human Blood. Positive IHC detected in human liver cancer tissue, human liver tissue. Positive FC detected in HepG2 cells. Observed molecular weight by Western-blot: 23 kDa
  • Tested applications
    ELISA, WB, IHC, FC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    Plasma retinol binding protein antibody; PRBP antibody; RBP antibody; RBP4 antibody; Retinol binding protein 4 antibody
  • Isotype
    Mouse IgG2a
  • Preparation
    This antibody was obtained by immunization of RBP4 recombinant protein (Accession Number: NM_006744). Purification method: Protein A purified.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:1000-1:10000

    IHC: 1:20-1:200

  • Validations

    human blood tissue were subjected to SDS PAGE followed by western blot with Catalog No:107502(RBP4 antibody) at dilution of 1:4000

    human blood tissue were subjected to SDS PAGE followed by western blot with Catalog No:107502(RBP4 antibody) at dilution of 1:4000

    Immunohistochemistry of paraffin-embedded human liver cancer slide using Catalog No:107502(RBP4 Antibody) at dilution of 1:50

    Immunohistochemistry of paraffin-embedded human liver cancer slide using Catalog No:107502(RBP4 Antibody) at dilution of 1:50

    Immunohistochemistry of paraffin-embedded human liver cancer slide using Catalog No:107502(RBP4 Antibody) at dilution of 1:50

    Immunohistochemistry of paraffin-embedded human liver cancer slide using Catalog No:107502(RBP4 Antibody) at dilution of 1:50

    1X10^6 HepG2 cells were stained with 0.2ug RBP4 antibody (Catalog No:107502, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L) with dilution 1:1000.

    1X10^6 HepG2 cells were stained with 0.2ug RBP4 antibody (Catalog No:107502, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L) with dilution 1:1000.

  • Background
    RBP4 (retinol-binding protein 4) is a carrier protein that transports vitamin A (retinol) from the liver to the peripheral tissues. Synthesized primarily by hepatocytes and adipocytes as a 21 kDa non-glycosylated protein, RBP4 is secreted into the circulation as a retinol-RBP4 complex. In plasma the RBP4-retinol complex is bound to transthyretin (TRR), which prevents prevent kidney filtration. Two truncated forms of RBP4, RBP4-L (truncated at Leu-183) and RBP4-LL (truncated at Leu-182 and Leu-183), exist by proteolytic process. RBP4-L and RBP4-LL, which do not bind TTR, are normally excreted into the urine but accumulate in the serum during renal failure. Urinary RBP4 has been reported as marker for glomerular disease. RBP4 also was identified as an adipokine that elevated in some insulin-resistant states. Measurement of serum RBP4 could be used to assess the risk of insulin resistance, type 2 diabetes, obesity, and cardiovascular disease. (18752671, 16034410)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"