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Product Name
Recombinant RBM8A protein (His tag)
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Description
Introducing the recombinant RNA-binding protein 8A (RBM8A) fragment (amino acids 2-174), a high-purity tool designed for studying the RRM domain's role in pre-mRNA splicing and exon junction complex (EJC) assembly. This human-derived fragment enables targeted investigation of RNA-binding mechanisms and spliceosomal functions in gene regulation.
The full-length RNA-binding protein 8A (RBM8A) is a crucial component of the spliceosome and core exon junction complex (EJC) in humans. It plays essential roles in pre-mRNA splicing, nuclear mRNA export, translation efficiency, and nonsense-mediated mRNA decay (NMD). As part of the MAGOH-RBM8A heterodimer, it stabilizes the EJC on spliced mRNAs and regulates apoptotic gene splicing, including modulation of BCL2L1/Bcl-X isoforms. RBM8A exhibits nucleocytoplasmic shuttling, localizing to nuclear speckles and traveling to the cytoplasm as part of mRNA-bound EJC complexes, reflecting its dynamic involvement in multiple stages of mRNA metabolism.
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Protein name
RNA-binding protein 8A
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Uniprot ID
Q9Y5S9
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Gene Name
RBM8A; RBM8
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 2-174 aa (Q9Y5S9) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 21.41 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 26 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"