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Product Name
Recombinant RBBP5 protein (His tag)
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Description
Recombinant Retinoblastoma-binding protein 5 (RBBP-5) fragment (amino acids 1-404) from Homo sapiens. This stable and soluble fragment is ideal for investigating RBBP-5's role in transcriptional regulation and histone methylation, offering a reliable tool for structural and biochemical studies.
Retinoblastoma-binding protein 5 (RBBP-5) is a nuclear protein crucial for epigenetic regulation and cellular differentiation. It functions as a component of histone methyltransferase complexes, such as the MLL1/MLL complex, where it facilitates mono-, di-, and trimethylation at 'Lys-4' of histone H3—a key marker for transcriptional activation. RBBP-5, in association with proteins like ASH2L and WDR5, enhances the methyltransferase activity of enzymes including KMT2A, KMT2B, KMT2C, KMT2D, SETD1A, and SETD1B, playing a vital role in gene induction during processes like neural lineage differentiation in embryonic stem cells. Its localization in the nucleus underscores its involvement in chromatin remodeling and developmental gene regulation.
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Protein name
Retinoblastoma-binding protein 5
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Uniprot ID
Q15291
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Gene Name
RBBP5; RBQ3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-404 aa (Q15291) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 46.70 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 52 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"