Recombinant RB39B protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Ras-related protein Rab-39B (EC 3.6.5.2) fragment (residues 1-213) is a high-purity, soluble protein designed for structural and functional studies. This fragment encompasses the full-length protein and is optimized for stability, making it an ideal tool for investigating intracellular membrane trafficking, autophagy, and synaptic regulation mechanisms.

Ras-related protein Rab-39B (RAB39B) is a small GTPase that acts as a key regulator of intracellular membrane trafficking, cycling between inactive GDP-bound and active GTP-bound states to coordinate vesicle formation, movement, tethering, and fusion. It plays a critical role in autophagy, contributing to autophagosome formation, and interacts with downstream effectors like PICK1 to regulate AMPA receptor composition and synaptic transmission. RAB39B is also implicated in maintaining SNCA/alpha-synuclein homeostasis. The protein localizes to the cell membrane, cytoplasmic vesicles (including autophagosomes and autolysosomes), and the Golgi apparatus, where it anchors to membranes via lipid modifications on the cytoplasmic side, highlighting its importance in cellular transport and neurodegenerative processes.