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Rat IFN-alpha / IFNA1 / IFN (Fc Tag) recombinant protein

Cat.#: 503755

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Product Information

  • Product Name
    Rat IFN-alpha / IFNA1 / IFN (Fc Tag) recombinant protein
  • Documents
  • Description
    IFNA1, also known as IFN-alpha and IFNA, belongs to the alpha/beta interferon family. Interferons(IFNs) are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites or tumor cells. They belong to the large class of glycoproteins known as cytokines. IFNs stimulate the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow for communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. IFNs can activate immune cells, such as natural killer cells and macrophages; they increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes; and they also increase the ability of uninfected host cells to resist new infection by virus.Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon is produced by mitogen- or antigen-stimulated T lymphocytes. IFNA1 is produced by macrophages and has antiviral activities.
  • Protein name
    Interferon alpha-1
  • Protein short names
    IFN; IFN-ALPHAD; MGC138505; IFN-ALPHA-1; LEIF D; INTERFERON ALPHA-1/13; IFN-ALPHA 1B; INTERFERON ALPHA 1B; MGC138207; IFA1; MGC138507; INTERFERON-ALPHA1; IFNA13; INTERFERON ALPHA-D; IFNA ; INTERFERON ALPHA-1; IFL; RP23-360M23.1; IFN-ALPHA-1/13; IFN-ALPHA; INTERFERON ALPHA FAMILY GENE 1
  • Uniprot ID
    P05011
  • Gene Name
    Ifna1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rat IFNA1 (P05011) (Met 1-Ser 192) was fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Rat
  • Molecular weight
    The recombinant rat IFNA1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 410 amino acids and predicts a molecular mass of 46.4 kDa. The apparent molecular mass of the rat IFNA1/Fc monomer is approximately 50 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Activity
    Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV).
    The ED50 for this effect is 1-10 μg/mL.
  • Validations

    Rat IFN-alpha / IFNA1 / IFN Protein (Fc Tag) SDS-PAGE

    Rat IFN-alpha / IFNA1 / IFN Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"