Recombinant RASF1 protein (His tag)

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Recombinant Human RASSF1 (Ras association domain-containing protein 1) Fragment (aa 48-344) – a high-purity protein fragment encompassing the Ras-associating and SARAH domains, ideal for investigating tumor suppressor mechanisms, apoptosis regulation, and cell cycle control in cancer research.

RASSF1 is a potential tumor suppressor protein in humans, essential for death receptor-dependent apoptosis. It mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation and, in association with MOAP1, promotes BAX conformational change and mitochondrial translocation in response to TNF and TNFSF10 stimulation. Isoform A inhibits cell proliferation by negatively regulating G1/S-phase transition through cyclin D1 accumulation, disrupts MDM2-DAXX-USP7 interactions to activate TP53 in DNA damage response, and localizes to cytoplasmic microtubules, centrosomes, spindle fibers, and the nucleus during cell division. This fragment includes the Ras-associating and SARAH domains, enabling focused study of these critical functional regions.