RANATUERIN 2P peptide

RANATUERIN 2P peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

GLMDTVKNVAKNLAGHMLDKLKCKITGC

Gly-Leu-Met-Asp-Thr-Val-Lys-Asn-Val-Ala-Lys-Asn-Leu-Ala-Gly-His-Met-Leu-Asp-Lys-Leu-Lys-Cys-Lys-Ile-Thr-Gly-Cys

28

95.8%

Synthetic

Powder

Disulfide bridge: C22,C27. Active against S. aureus (MIC 50 uM), E. coli (MIC 13 uM), and C. albicans (MIC 67 uM). This peptide could inhibit HIV infection at a concentration that is also toxic to T cells (J Virol 2005; 79:11598-11606). Found in multiple species. Updated 3/2015. The source of RANATUERIN 2P is North American frog, Rana pipiens , ALSO: the Oregon spotted frog Rana pretiosa.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Goraya J, Wang Y, Li Z, et al. Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens. Eur J Biochem. 2000;267(3):894-900.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.