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  • Ranalexin peptide

Ranalexin peptide

Not For Human Use, Lab Use Only.

Cat.#: 315352

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    Ranalexin peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    FLGGLIKIVPAMICAVTKKC (disulfide bridge:Cys14-Cys20)
  • Sequence
    Phe-Leu-Gly-Gly-Leu-Ile-Lys-Ile-Val-Pro-Ala-Met-Ile-Cys-Ala-Val-Thr-Lys-Lys-Cys (disulfide bridge:Cys14-Cys20)
  • Length (aa)
    20
  • Peptide Purity (HPLC)
    95.5%
  • Molecular Formula
    C97H167N23O22S3
  • Molecular Weight
    2103.71
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Ranalexin is a 20-amino acid antimicrobial peptide isolated from the skin of the American bullfrog, Rana catesbeiana. Its sequence is Phe-Leu-Gly-Gly-Leu-Ile-Lys-Ile-Val-Pro-Ala-Met-Ile-Cys-Ala-Val-Thr-Lys-Lys-Cys, featuring a single intramolecular disulfide bond that forms a heptapeptide ring. Structurally, Ranalexin resembles the bacterial antibiotic polymyxin, which also contains a similar heptapeptide ring. The peptide is initially synthesized as a propeptide with a putative signal sequence and an acidic amino acid-rich region at its amino-terminal end.

    Ranalexin mRNA expression begins during metamorphosis in R. catesbeiana and persists into adulthood, primarily in the granular glands of the skin. The peptide exhibits broad-spectrum antimicrobial activity, with its hydrophobic amino-terminal region and the integrity of the disulfide-bonded ring being critical for its function. The structural and functional similarities between Ranalexin and polymyxin suggest a conserved mechanism of membrane interaction in antimicrobial peptides.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Clark DP, Durell S, Maloy WL, Zasloff M. Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin. J Biol Chem. 1994 Apr 8;269(14):10849-55. PMID: 8144672.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

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  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"