Recombinant RAN protein (His tag)

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Recombinant GTP-binding nuclear protein ran-1 (Ras-related nuclear protein 1) fragment from Caenorhabditis elegans, encompassing residues 1-215. This high-purity protein includes the complete Small GTPase Ran-type domain, making it an essential tool for investigating nucleocytoplasmic transport, mitotic regulation, and nuclear envelope dynamics in cellular studies.

GTP-binding nuclear protein ran-1 is a key component of the Ran GTPase system, which is critical for nucleocytoplasmic transport, mediating both protein import into the nucleus and RNA export. It plays a vital role in mitotic processes by facilitating interactions between chromosomes and kinetochore microtubules and is indispensable for nuclear envelope reassembly following cell division. The RCC1/Ran complex also functions in a pathway that detects unreplicated DNA. Subcellular localization studies reveal that ran-1 is predominantly nuclear during interphase, associates with kinetochores from late metaphase to anaphase, and redistributes around decondensing chromosomes at telophase, underscoring its dynamic involvement in cell cycle progression and structural organization.