Recombinant RAB4B protein (His tag)

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Recombinant Human Ras-related protein Rab-4B (EC 3.6.5.2) fragment (residues 2-213) is a high-quality, stable protein designed for structural and biochemical studies. This 212-amino acid fragment retains key functional regions, offering researchers a reliable tool to investigate intracellular membrane trafficking and endosomal dynamics.

Ras-related protein Rab-4B is a small GTPase that plays a critical role in regulating intracellular membrane trafficking processes, including vesicle formation, movement, tethering, and fusion. It cycles between inactive GDP-bound and active GTP-bound states to recruit downstream effectors. Specifically, RAB4B mediates endosomal tethering and fusion through interactions with RUFY1 and RAB14, and it regulates platelet alpha-granule release during platelet activation and aggregation. The protein is localized to the cell membrane and early endosome membrane, where it is lipid-anchored on the cytoplasmic side. This recombinant fragment (residues 2-213) encompasses the stable, soluble core domain, enabling detailed analysis of its functional mechanisms in cellular trafficking pathways.