Recombinant RAB35 protein (His tag)

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Recombinant Human Ras-related protein Rab-35 (RAB35) fragment (amino acids 1-201) is a high-purity, stable protein designed for structural and biochemical studies. This fragment encompasses key functional domains essential for investigating Rab-35's role in intracellular membrane trafficking, endocytosis, and cytokinesis, providing researchers with a reliable tool for elucidating GTPase-mediated cellular processes.

Ras-related protein Rab-35 is a small GTPase that acts as a critical regulator of intracellular membrane trafficking, cycling between inactive GDP-bound and active GTP-bound states to control vesicle formation, movement, and fusion. It plays a pivotal role in endocytosis and the fast recycling pathway to the plasma membrane, and is essential for cytokinesis, where it stabilizes the intercellular bridge and facilitates abscission. Rab-35 also localizes to endosomes, clathrin-coated pits/vesicles, melanosomes, and PIP2-enriched membrane domains, and may influence neurite outgrowth and insulin-induced GLUT4 translocation in adipocytes. Its involvement in key cellular processes makes it a significant target for research in membrane dynamics, cell division, and metabolic regulation.