Recombinant RAB24 protein (His tag)

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Recombinant Human Ras-related protein Rab-24 (EC 3.6.5.2) fragment (amino acids 1-203) is a high-quality, soluble protein designed for structural and biochemical studies. This fragment represents a stable, functional unit of RAB24, an atypical GTPase involved in intracellular membrane trafficking and autophagy regulation, making it an ideal tool for investigating vesicle dynamics and cellular clearance mechanisms.

Ras-related protein Rab-24 (RAB24) is a member of the Rab GTPase family, key regulators of intracellular membrane trafficking processes such as vesicle formation, movement, and fusion. Unlike typical Rab proteins, RAB24 exhibits low GTPase activity, predominantly existing in the active GTP-bound state. It plays a critical role in the clearance of late autophagic vacuoles under basal conditions, though it is not required for starvation-induced autophagy. Additionally, RAB24 is involved in modulating meiotic apparatus assembly and progression during oocyte maturation, potentially through regulation of kinetochore-microtubule interactions. Subcellular localization studies indicate that RAB24 is found in the cytoplasm, cytosol, membranes (via lipid anchors), autophagosome membranes, perinuclear regions, and the spindle apparatus during meiosis, highlighting its diverse roles in cellular organization and trafficking pathways.