Recombinant RAB17 protein (His tag)

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Introducing the recombinant Ras-related protein Rab-17 (EC 3.6.5.2) fragment, encompassing amino acids 1-212. This high-quality protein is derived from Homo sapiens and represents a stable, soluble unit ideal for investigating intracellular membrane trafficking, transcytosis, and cellular transport mechanisms in structural and biochemical studies.

Ras-related protein Rab-17 is a small GTPase that serves as a critical regulator of intracellular membrane trafficking, cycling between inactive GDP-bound and active GTP-bound states to coordinate vesicle formation, movement, tethering, and fusion. Specifically, RAB17 facilitates transcytosis, the directional transport of endocytosed material across epithelial cells, such as immunoglobulins from basolateral to apical surfaces. It operates in apical recycling endosomes during post-endocytic transcytosis and is involved in melanosome transport and release, dendrite and dendritic spine development, and cell migration. The protein localizes to recycling endosome membranes, melanosomes, dendrites, and cell projections, with potential presence at basolateral and apical plasma membranes, highlighting its role in polarized cellular processes.