Recombinant PURB protein (His tag)

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Recombinant Human Transcriptional Regulator Protein Pur-beta (PURB) Fragment (aa 31-312) is a high-purity, stable protein fragment designed for structural and biochemical studies. This 282-amino acid fragment retains key functional characteristics of the full-length protein, offering researchers a reliable tool to investigate Pur-beta's role in transcriptional regulation and nucleic acid binding.

Transcriptional regulator protein Pur-beta (Purine-rich element-binding protein B), encoded by the PURB gene in humans, is a versatile transcriptional modulator capable of both activating and repressing gene expression. It represses transcription of ACTA2 and MYOCD genes by interacting with purine-rich elements in their regulatory regions, while activating ADCY6 transcription to promote hepatic glucose production. The protein demonstrates specific binding capacity to purine-rich single-stranded DNA elements, such as those found upstream of the MYC gene, and participates in transcriptional regulation of alpha-MHC in cardiac myocytes and galectin-3 in liver cells. Pur-beta is primarily localized to the nucleus, where it exerts its regulatory functions, and may also play roles in mRNA transport within dendritic cells.