Recombinant PTPRB protein (His tag)

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Recombinant Human Receptor-type tyrosine-protein phosphatase beta (PTPRB) fragment (residues 1681-1997) is a high-purity protein designed for studying tyrosine phosphatase activity and its regulatory roles in vascular biology. This fragment encompasses the essential Tyrosine-protein phosphatase domain, making it an ideal tool for investigating specific enzymatic functions and signaling mechanisms in endothelial cells.

Receptor-type tyrosine-protein phosphatase beta (PTPRB), also known as Vascular endothelial protein tyrosine phosphatase (VE-PTP), is a membrane-anchored enzyme crucial for blood vessel maintenance and angiogenesis. It plays a key role in vascular remodeling by dephosphorylating critical endothelial receptors such as TEK/TIE2, CDH5/VE-cadherin, and KDR/VEGFR-2. PTPRB regulates angiopoietin-TIE2 signaling, controls endothelial cell proliferation, and maintains endothelial cell contact integrity through its interaction with VE-cadherin and plakoglobin. As a single-pass type I membrane protein, it functions at the cell membrane to modulate vascular development and stability during embryonic and perinatal growth.

1681-1997