Recombinant PTN protein (His tag)

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Recombinant Human Pleiotrophin (PTN) Fragment (aa 33-168) - A highly purified, stable protein fragment ideal for investigating the multifaceted roles of this heparin-binding growth factor in neuronal development, bone formation, and cellular signaling pathways.

Pleiotrophin (PTN), also known as Heparin-binding Growth Factor 8 or Osteoblast-specific Factor 1, is a secreted growth factor that mediates signaling through cell-surface proteoglycan and non-proteoglycan receptors. This multifunctional protein regulates critical processes including cell proliferation, survival, differentiation, and migration in neuronal and bone tissues. PTN binds to receptors such as PTPRZ1, ALK, and various proteoglycans, activating key signaling pathways including PI3K-AKT and MAPK. The protein plays essential roles in synaptic plasticity, dendritic arborization, oligodendrocyte differentiation, bone formation, and hematopoietic regeneration. As a secreted protein, PTN functions in the extracellular environment where it interacts with cell surface receptors to coordinate complex biological processes across multiple tissue systems.

33-168