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Product Name
Recombinant PTGR2 protein (His tag)
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Description
Recombinant Human Prostaglandin reductase 2 (PRG-2) fragment (amino acids 1-351) is a high-purity protein designed for structural and biochemical studies. This fragment encompasses the full-length protein and is optimized for stability and solubility, making it an ideal tool for investigating prostaglandin metabolism and PPARG transcriptional regulation.
Prostaglandin reductase 2 (PRG-2), encoded by the PTGR2 gene in humans, functions as a 15-oxoprostaglandin 13-reductase (EC 1.3.1.48) with highest activity towards 15-keto-PGE2. It catalyzes the reduction of 15-keto prostaglandins, including 15-keto-PGE1, 15-keto-PGE2, and their alpha variants, playing a key role in prostaglandin inactivation and metabolic pathways. Additionally, PRG-2 overexpression represses PPARG transcriptional activity and inhibits adipocyte differentiation, highlighting its significance in lipid metabolism and cellular differentiation processes. The protein is localized in the cytoplasm, where it performs its enzymatic functions.
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Protein name
Prostaglandin reductase 2
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Uniprot ID
Q8N8N7
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Gene Name
PTGR2; ZADH1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-351 aa (Q8N8N7) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 40.16 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 40 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"