Recombinant PTGR1 protein (His tag)

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Recombinant Human Prostaglandin Reductase 1 (PRG-1) Fragment (residues 1-329) is a high-purity, soluble protein designed for structural and biochemical studies. This fragment encompasses the full-length functional domain, offering researchers a stable tool to investigate its NAD(P)H-dependent oxidoreductase activity in metabolizing key inflammatory eicosanoids like prostaglandins and leukotrienes.

Prostaglandin Reductase 1 (PRG-1), encoded by the PTGR1 gene, is a cytoplasmic NAD(P)H-dependent oxidoreductase critical for the metabolic inactivation of pro- and anti-inflammatory eicosanoids, including prostaglandins (PGs), leukotrienes (LTs), and lipoxins (LXs). It efficiently reduces the 13,14 double bond of 15-oxo-prostaglandins and oxidizes the C12 hydroxyl group of leukotriene B4 (LTB4), converting these mediators into less active metabolites. Additionally, PRG-1 may contribute to detoxification by reducing cytotoxic alpha,beta-unsaturated alkenals and ketones, such as 4-hydroxy-2-nonenal, and plays a role in modulating neutrophil recruitment during inflammation through its action on lipoxins. This recombinant fragment (residues 1-329) represents a stable, soluble unit ideal for elucidating the enzyme's mechanisms in eicosanoid metabolism and inflammatory pathways.