Recombinant PTEN protein (His tag)

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Recombinant Human PTEN Protein Fragment (residues 2-282) is a high-purity, functionally active protein encompassing the critical phosphatase tensin-type domain (residues 14-185). This fragment serves as an essential tool for investigating PTEN's dual-specificity phosphatase and lipid phosphatase activities, enabling targeted studies of its role in key signaling pathways, cell cycle regulation, and tumor suppression.

PTEN (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase) is a crucial tumor suppressor protein in humans that antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and tyrosine-, serine-, and threonine-phosphorylated proteins. It modulates cell cycle progression, cell survival, migration, and synaptic function, with mutations linked to multiple advanced cancers. The full-length protein localizes to both cytoplasm and nucleus, where monoubiquitinated forms exhibit enhanced nuclear localization and apoptotic potential. This recombinant fragment (2-282) retains the core phosphatase tensin-type domain, allowing focused investigation of PTEN's enzymatic mechanisms and regulatory functions without interference from other structural elements.