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Product Name
Recombinant PSMD9 protein (His tag)
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Description
This product is a recombinant fragment of the human 26S proteasome non-ATPase regulatory subunit 9 (PSMD9), encompassing amino acids 1-223. It includes the full PDZ domain, making it an ideal tool for investigating the chaperone activity and regulatory mechanisms of the 26S proteasome assembly process in biochemical and functional studies.
The full-length 26S proteasome non-ATPase regulatory subunit 9, encoded by the PSMD9 gene in Homo sapiens, functions as a chaperone during the assembly of the 26S proteasome. It specifically aids in the formation of the base subcomplex of the PA700/19S regulatory complex (RC). During assembly, PSMD9 is part of an intermediate PSMD9:PSMC6:PSMC3 module, known as the modulator trimer complex, and is released as the base assembly progresses. This highlights its critical role in ensuring proper proteasome structure and function, which is essential for cellular protein degradation and homeostasis.
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Protein name
26S proteasome non-ATPase regulatory subunit 9
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Uniprot ID
O00233
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Gene Name
PSMD9
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-223 aa (O00233) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 26.34 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 27 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"