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Product Name
Recombinant PSMD3 protein (His tag)
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Description
Recombinant Human 26S Proteasome Non-ATPase Regulatory Subunit 3 (PSMD3) Fragment (aa 163-534) – a high-purity protein fragment encompassing the complete PCI domain, engineered for targeted studies of proteasome regulatory mechanisms and domain-specific functions in protein homeostasis.
The full-length 26S proteasome non-ATPase regulatory subunit 3 (PSMD3) is an essential component of the 26S proteasome, a multiprotein complex responsible for ATP-dependent degradation of ubiquitinated proteins. This complex is critical for maintaining cellular protein homeostasis by eliminating misfolded, damaged, or obsolete proteins, thereby supporting vital processes such as cell cycle progression, apoptosis, and DNA damage repair. The provided fragment spans residues 163-534 and includes the entire PCI domain (aa 286-465), enabling focused investigation into the structural and functional roles of this domain within the proteasome's regulatory machinery.
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Protein name
26S proteasome non-ATPase regulatory subunit 3
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Uniprot ID
O43242
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Gene Name
PSMD3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 163-534 aa (O43242) were fused with 6His tag.
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Sequence
163-534
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 45.01 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 46 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"