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Product Name
Prothymosin alpha antibody
- Documents
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Description
Prothymosin alpha Rabbit Polyclonal antibody. Positive IHC detected in human lymphoma tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
Prothymosin alpha antibody; prothymosin antibody; alpha antibody; PTMA antibody; TMSA antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Prothymosin alpha recombinant protein (Accession Number: NM_002823). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:114223(PTMA antibody) at dilution of 1:100 (under 25x lens)
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Background
Prothymosin alpha (PTMA) is a nuclear protein possessing a number of cellular functions including cell survival. PTMA is identified to be localized in the nuclei of neurons, while it is found in both nuclei and cytoplasm in the astrocytes and microglia of adult brai. PTMA inhibits the neuronal necrosis induced by serum-free starvation or ischemia-reperfusion stress, which causes a rapid internalization of GLUT1/4, leading a decrease in glucose uptake and cellular ATP levels. Extensive research on PTMA showed that it is of clinical significance and potential medical use as they may serve as a molecular marker for cancer prognosis and/or as therapeutic agents for treating immunodeficiencies, autoimmune diseases and malignancies.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"