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Product Name
Human Betacellulin / BTC (Fc Tag) recombinant protein
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Description
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
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Protein name
Probetacellulin
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Protein short names
BETACELLULIN; BTC; BCN; PROBETACELLULIN
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Uniprot ID
P35070
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Gene Name
BTC
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human BTC (P35070) (Met1-Tyr111) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human BTC/Fc is a disulfide-linked homodimer. The reduced monomer comprises 321 amino acids and has a predicted molecular mass of 36 kDa. The apparent molecular mass of the protein is approximately 43-46 kDa in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells.
The ED50 for this effect is typically 5-40 ng/mL. -
Validations
Human BTC / Betacellulin Protein (Fc Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"