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Product Name
Recombinant PRKX protein (His tag)
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Description
Recombinant human PRKX protein fragment (residues 43-358), encompassing the complete protein kinase and AGC-kinase C-terminal domains. This high-purity fragment serves as an essential tool for investigating cAMP-dependent signaling mechanisms, cellular differentiation, and epithelial morphogenesis in research applications.
PRKX is a serine/threonine protein kinase that mediates cAMP signaling and plays critical roles in cellular differentiation and epithelial morphogenesis. It functions through phosphorylation of downstream targets including CREB, SMAD6, and PKD1, regulating processes such as myeloid cell differentiation, nephrogenesis (via stimulation of renal epithelial cell migration and tubulogenesis), and angiogenesis (through endothelial cell proliferation and vascular structure formation). The protein localizes to both cytoplasm and nucleus, with cAMP inducing nuclear translocation, highlighting its dynamic role in signal transduction pathways.
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Protein name
cAMP-dependent protein kinase catalytic subunit PRKX
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Uniprot ID
P51817
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Gene Name
PRKX; PKX1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 43-358 aa (P51817) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 38.41 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 39 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"