-
Product Name
Recombinant PRDM2 protein (His tag)
- Documents
-
Description
Introducing the recombinant PR domain zinc finger protein 2 (PRDM2) fragment (amino acids 1-161), a high-purity protein designed for studying histone methylation mechanisms. This fragment fully encompasses the SET domain, enabling targeted investigation of its role as a histone methyltransferase specific for H3 lysine-9 methylation.
PRDM2 functions as an S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3, playing a crucial role in epigenetic regulation. The protein may also act as a DNA-binding transcription factor, binding to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 gene and potentially acting as a transcriptional activator. PRDM2 is exclusively localized to the nucleus, where it performs its regulatory functions in gene expression and chromatin modification.
-
Protein name
PR domain zinc finger protein 2
-
Uniprot ID
Q13029
-
Gene Name
PRDM2; KMT8; RIZ
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
DNA encoding 1-161 aa (Q13029) were fused with 6His tag.
-
Protein Species
Human
-
Molecular weight
Predictes a molecular mass of 20.01 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 21 kDa band.
-
Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
-
Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"