-
Product Name
Recombinant PP2A protein (His tag)
- Documents
-
Description
Recombinant Drosophila melanogaster Serine/threonine-protein phosphatase PP2A (EC 3.1.3.16) fragment (amino acids 1-309) offers a stable and soluble unit ideal for structural studies and biochemical assays, enabling investigation of its catalytic role in transcription regulation and cellular signaling pathways.
The full-length Serine/threonine-protein phosphatase PP2A, encoded by the mts gene, functions as the catalytic subunit of the PP2A complex, regulating diverse enzymes, signal transduction, and cellular events. It serves as the major phosphatase for microtubule-associated proteins and plays a critical role in transcription elongation quality control as part of the Integrator-PP2A (INTAC) complex. Within INTAC, PP2A dephosphorylates the C-terminal domain of RNA polymerase II (POLR2A/RPB1) and Spt5, thereby promoting premature transcription termination and preventing elongation of unfavorably configured transcripts, highlighting its importance in gene expression regulation.
-
Protein name
Serine/threonine-protein phosphatase PP2A
-
Uniprot ID
P23696
-
Gene Name
mts; PP2A; Pp2A-28D
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
DNA encoding 1-309 aa (P23696) were fused with 6His tag.
-
Sequence
1-309
-
Protein Species
Drosophila melanogaster
-
Molecular weight
Predictes a molecular mass of 37.13 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 39 kDa band.
-
Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
-
Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"