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Product Name
Recombinant POP5 protein (His tag)
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Description
Recombinant Ribonuclease P/MRP protein subunit POP5 (hPop5) fragment (1-163) is a high-quality, stable protein designed for structural and biochemical studies. This soluble fragment retains key functional regions, making it ideal for investigating tRNA and rRNA processing mechanisms in vitro.
The full-length POP5 protein is a critical component of two essential ribonucleoprotein complexes in humans: ribonuclease P, which generates mature tRNA molecules by cleaving their 5'-ends, and the MRP ribonuclease complex, involved in pre-rRNA processing. Located in the nucleus and nucleolus, POP5 plays a fundamental role in RNA maturation and ribosomal biogenesis, underscoring its importance in gene expression and cellular function. The provided fragment encompasses the complete functional domain, enabling focused research on its molecular interactions and catalytic contributions.
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Protein name
Ribonuclease P/MRP protein subunit POP5
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Uniprot ID
Q969H6
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Gene Name
POP5
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-163 aa (Q969H6) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 20.47 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 21 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"