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Product Name
Recombinant PON1 protein (His tag)
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Description
Recombinant Human Serum Paraoxonase/Arylesterase 1 (PON1) Fragment (residues 2-355) is a high-purity protein designed for structural and biochemical studies. This 354-amino acid fragment retains key functional domains, offering a stable and soluble unit ideal for investigating organophosphate hydrolysis and oxidative stress protection mechanisms.
Serum paraoxonase/arylesterase 1 (PON1) is a secreted enzyme that hydrolyzes toxic organophosphorus compounds from insecticides and metabolizes a broad spectrum of substrates including lactones and aromatic esters. It plays a crucial protective role by preventing oxidative modification of low-density lipoproteins, thereby contributing to the reduction of atheroma formation and cardiovascular disease risk. The protein is naturally localized in the extracellular space, where it executes its detoxification and antioxidant functions.
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Protein name
Serum paraoxonase/arylesterase 1
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Uniprot ID
P27169
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Gene Name
PON1; PON
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 2-355 aa (P27169) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 41.26 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 42 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"