Recombinant PIN1 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Peptidyl-prolyl cis-trans isomerase Pin1 (PIN1) fragment (amino acids 1-163) is a high-purity protein designed for studying the molecular mechanisms of phosphorylation-dependent signaling and isomerization. This fragment includes the complete WW and PpiC functional domains, making it an ideal tool for investigating Pin1's role in cell cycle regulation, oncogenesis, and DNA repair pathways.

Peptidyl-prolyl cis-trans isomerase Pin1 (EC 5.2.1.8) is a phosphorylation-specific PPIase that isomerizes phosphorylated Ser/Thr-Pro motifs, acting as a critical molecular switch in cellular processes including mitosis, oncogene transactivation, and DNA damage response. It regulates key proteins such as NIMA, BTK, RAF1, PML, and FBXW7, influencing centrosome amplification, JNK signaling, and repair pathway choice between error-prone NHEJ and homologous recombination. Pin1 localizes primarily to the nucleus and nuclear speckles, with phosphorylation-dependent regulation of its subcellular distribution. Its involvement in hypoxia responses and inflammatory signaling further underscores its broad functional significance in cellular homeostasis and disease contexts.