Recombinant PILRA protein (His tag)

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Recombinant Human PILRA Protein Fragment (aa 32-154) - A high-purity protein fragment encompassing the complete Ig-like V-type domain of Paired immunoglobulin-like type 2 receptor alpha, designed for functional studies of this key immune regulatory receptor.

Paired immunoglobulin-like type 2 receptor alpha (PILRA) functions as a cellular signaling inhibitory receptor in the human immune system. It regulates immune responses by recruiting cytoplasmic phosphatases such as PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains, which block signal transduction through dephosphorylation of signaling molecules. PILRA serves as a receptor for PIANP and also acts as an entry co-receptor for herpes simplex virus 1 infection. The full-length protein is primarily localized to the cell membrane as a single-pass type I membrane protein, though alternative isoforms exist as secreted forms. This recombinant fragment specifically targets the functional Ig-like V-type domain, enabling focused investigation of PILRA's receptor interactions and signaling mechanisms.