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Product Name
Recombinant PHS2 protein (His tag)
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Description
Recombinant Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) fragment (amino acids 32-130) from Homo sapiens, produced to support studies in tetrahydrobiopterin biosynthesis and transcriptional regulation. This 99-amino acid fragment is engineered for stability and solubility, ideal for structural and biochemical research applications.
Pterin-4-alpha-carbinolamine dehydratase 2 (encoded by PCBD2) plays a dual role in cellular processes. It contributes to tetrahydrobiopterin biosynthesis by preventing the formation of 7-pterins and accelerating quinonoid-BH2 production. Additionally, it functions as a dimerization cofactor for hepatocyte nuclear factor 1-alpha (HNF-1-alpha), enhancing its transcriptional activity. These functions highlight its importance in both metabolic and gene regulatory pathways, making it a valuable target for research in enzymology and transcriptional mechanisms.
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Protein name
Pterin-4-alpha-carbinolamine dehydratase 2
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Uniprot ID
Q9H0N5
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Gene Name
PCBD2; DCOH2; DCOHM
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 32-130 aa (Q9H0N5) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 13.05 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 13 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"