Phospho-GRIA2-S880 pAb

Cat.#: 166374

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Product Information

  • Product Name
    Phospho-GRIA2-S880 pAb
  • Documents
  • Description
    Polyclonal antibody to Phospho-GRIA2-S880
  • Tested applications
    WB
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    GRIA2 antibody; GLUR2 antibody; GLURB antibody; GluA2 antibody; GluR-K2 antibody; HBGR2 antibody; glutamate receptor 2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A phospho specific peptide corresponding to residues surrounding S880 of human GRIA2
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
  • Validations

    Western blot - Phospho-GRIA2-S880 pAb

    Western blot - Phospho-GRIA2-S880 pAb

    Western blot analysis of extracts from mouse brain tissue using Phospho-GRIA2-S880 antibody and the same antibody preincubated with blocking peptide.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.

  • Background
    Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"