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  • phospho(403/404)-TDP43 antibody

phospho(403/404)-TDP43 antibody

Cat.#: 107469

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Product Information

  • Product Name
    phospho(403/404)-TDP43 antibody
  • Documents
  • Description
    phospho(403/404)-TDP43 Mouse Monoclonal antibody. Positive WB detected in K-562 cells, human placenta tissue. Observed molecular weight by Western-blot: 25 kDa
  • Tested applications
    ELISA, WB
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    ALS10 antibody; TAR DNA binding protein antibody; TAR DNA binding protein 43 antibody; TARDBP antibody; TDP 43 antibody; TDP43 antibody
  • Isotype
    IgG2a
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_007375). Purification method: Protein A purified.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

  • Validations

    K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:107469(phospho(403/404)-TDP43 antibody) at dilution of 1:1000

    K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:107469(phospho(403/404)-TDP43 antibody) at dilution of 1:1000

  • Background
    Transactivation response (TAR) DNA-binding protein of 43 kDa (also known as TARDBP or TDP-43) was first isolated as a transcriptional inactivator binding to the TAR DNA element of the HIV-1 virus. Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP-43, is the major component of the tau-negative and ubiquitin-positive inclusions that characterize amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U). 66079-1-Ig is a mouse monoclonal antibody recognizing TDP-43 only when phosphorylated at 403/404. This antibody detects phosphorylated forms of TDP-43 as well as the cleavage product of 20-30 kDa. Immunohistochemical analyses using this antibody only stain the insoluble inclusions in pathologic tissues without normal diffuse nuclear staining.
  • References
    • Kovacs GG, van der Zee J, Hort J. Clinicopathological description of two cases with SQSTM1 gene mutation associated with frontotemporal dementia. Neuropathology : official journal of the Japanese Society of Neuropathology. 36(1):27-38. 2016.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"