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Product Name
PHC3 Polyclonal Antibody
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Description
Polyclonal antibody to PHC3
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Tested applications
IF
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Species reactivity
Human
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Alternative names
PHC3 antibody; EDR3 antibody; HPH3 antibody; polyhomeotic homolog 3 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human PHC3 (NP_079223.3).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
IF 1:50 - 1:100
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Validations
Immunofluorescence - PHC3 Polyclonal Antibody
Immunofluorescence analysis of U2OS cells using PHC3 antibody . Blue: DAPI for nuclear staining.
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Background
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"