Recombinant PGRP1 protein (His tag)

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Recombinant Human Peptidoglycan Recognition Protein 1 (PGRP-S), encompassing amino acids 22-196, is a high-purity fragment designed to include the complete N-acetylmuramoyl-L-alanine amidase domain. This product offers researchers a targeted tool to investigate innate immune responses, bacterial recognition, and antimicrobial mechanisms, supporting studies in immunology and infectious disease.

Peptidoglycan Recognition Protein 1 (PGLYRP1) is a secreted innate immunity protein critical for antimicrobial and antitumor defense. It functions as a pattern recognition receptor that binds peptidoglycans from Gram-positive bacteria, providing direct bactericidal activity. Beyond microbial defense, PGRP-S forms complexes with HSPA1A to induce tumor cell death via apoptosis and necroptosis through TNFR1 activation. It also partners with S100A4 to act as a chemoattractant for immune cells by engaging CCR5 and CXCR3 receptors, enhancing lymphocyte migration and cytotoxicity against virus-infected and tumor cells. Additionally, it requires TREM1 receptor interaction for monocyte-mediated cytotoxicity. The protein is naturally secreted and localized to cytoplasmic granules, underscoring its role in extracellular immune signaling and intracellular storage.