Recombinant PDX1 protein (His tag)

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Recombinant PDX-1 (116-243) is a 128-amino acid fragment of the human Pancreas/duodenum homeobox protein 1, designed for structural and biochemical studies. This stable, soluble unit retains key functional relevance, supporting research on transcriptional regulation in pancreatic development and diabetes.

PDX-1 is a critical transcription factor in humans that activates genes such as insulin, somatostatin, glucokinase, and glucose transporter type 2, playing a central role in glucose-dependent insulin gene regulation. It binds DNA motifs like 5'-[CT]TAAT[TG]-3' and forms complexes (e.g., with PBX1b and MEIS2b) to enhance transcription in pancreatic cells. During development, PDX-1 specifies pancreatic epithelium and promotes proliferation and differentiation, while in adults, it maintains beta-cell hormone production. The protein localizes to the nucleus and cytoplasm, underscoring its dynamic regulatory functions in metabolic homeostasis and pancreatic biology.