Recombinant PDGFC protein (His tag)

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Recombinant Human PDGF-C (Platelet-derived growth factor C) Fragment (aa 46-215) is a high-purity protein designed for studying the specific functions of the CUB domain. This fragment supports research into cell proliferation, migration, and developmental processes, offering a targeted tool for investigating PDGF-C's roles in angiogenesis, wound healing, and fibrotic pathways.

Platelet-derived growth factor C (PDGF-C) is a critical growth factor in human biology, essential for embryonic development, cell proliferation, migration, survival, and chemotaxis. It acts as a potent mitogen and chemoattractant for mesenchymal cells, playing key roles in craniofacial and skeletal formation, skin morphogenesis, wound healing (involving inflammation, proliferation, and remodeling stages), angiogenesis, and fibrotic processes. The CUB domain, included in this fragment, exhibits mitogenic activity in coronary artery smooth muscle cells and may function beyond maintaining PDGF domain latency. PDGF-C is localized in the cytoplasm, cytosol, secreted form, nucleus, cytoplasmic granules, and cell membrane, with sumoylated forms predominant in the nucleus and storage in platelet alpha granules, highlighting its diverse cellular roles and importance in physiological and pathological contexts.