Recombinant PDE6D protein (His tag)

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Recombinant Human Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) Fragment (1-150) is a high-purity protein fragment designed for structural and biochemical studies. This stable, soluble unit retains key functional regions, enabling researchers to investigate its role in prenylated protein trafficking and ciliary targeting with enhanced experimental versatility.

The full-length PDE6D protein, encoded by the PDE6D gene in Homo sapiens, functions as a critical regulator of prenylated and palmitoylated target proteins. It promotes the release of these proteins from cellular membranes and modulates the activity of Ras family members by controlling their subcellular localization. PDE6D is essential for normal ciliary targeting of farnesylated proteins like INPP5E and facilitates RAB28 localization in retinal cone cell outer segments. Acting as a GTP-specific dissociation inhibitor (GDI), it stabilizes ARL3-GTP by significantly increasing GTP affinity and reducing nucleotide dissociation rates. Subcellularly, PDE6D localizes to the cytoplasm (cytosol), cytoplasmic vesicle membranes as a peripheral membrane protein, and the cilium basal body, underscoring its involvement in membrane dynamics and ciliary function.