Recombinant PD1L1 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human PD-L1 (CD274) Fragment (aa 19-238) is a high-purity protein encompassing the essential Ig-like V-type and C2-type domains. This fragment serves as a critical tool for investigating immune checkpoint regulation, T-cell modulation, and cancer immunotherapy mechanisms, providing researchers with a reliable reagent for functional and binding studies.

Programmed cell death 1 ligand 1 (PD-L1), encoded by the CD274 gene, plays a pivotal role in immune tolerance and T-cell regulation. As the primary ligand for PD-1, PD-L1 modulates T-cell activation thresholds and effector responses, serving as a key immune checkpoint. The protein's significance extends to cancer biology, where tumor cells exploit the PD-1/PD-L1 pathway to evade immune destruction, making it a major target for immunotherapy. PD-L1 exhibits complex cellular localization, primarily residing at the cell membrane as a single-pass type I membrane protein, with additional presence in endosomal compartments and nuclear translocation under hypoxic conditions. The recombinant fragment (aa 19-238) contains the complete extracellular Ig-like domains responsible for PD-1 binding and immune regulatory functions.