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Product Name
Recombinant PCGF6 protein (His tag)
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Description
Recombinant Human PCGF6 (Polycomb group RING finger protein 6) fragment (residues 87-350) is a high-purity protein designed for structural and biochemical studies. This 264-amino acid fragment offers a stable and soluble unit ideal for investigating the transcriptional repressor functions and Polycomb group complex interactions of PCGF6.
PCGF6 (Polycomb group RING finger protein 6) is a transcriptional repressor that plays a critical role in maintaining gene silencing through chromatin remodeling. As a component of the Polycomb repressive complex 1 (PRC1)-like complex, it regulates RNF2 ubiquitin ligase activity and mediates monoubiquitination of histone H2A at lysine 119, leading to heritable changes in chromatin expressibility. Additionally, PCGF6 may modulate histone H3K4Me3 levels by activating the KDM5D histone demethylase. The protein is localized to the nucleus, where it contributes to developmental gene regulation, including Hox gene repression. This recombinant fragment provides a valuable tool for dissecting these mechanisms without interference from full-length protein instability.
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Protein name
Polycomb group RING finger protein 6
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Uniprot ID
Q9BYE7
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Gene Name
PCGF6; MBLR; RNF134
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 87-350 aa (Q9BYE7) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 32.12 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 36 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"