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Product Name
Recombinant PAR6G protein (His tag)
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Description
Recombinant Human PAR-6 gamma (PARD6G) Fragment (aa 132-253) is a high-purity protein designed for studying cell polarization and asymmetrical division. This fragment includes the complete Pseudo-CRIB and PDZ domains, making it an ideal tool for domain-specific functional assays and interaction studies.
Partitioning defective 6 homolog gamma (PAR-6 gamma) is an adapter protein critical for asymmetrical cell division and epithelial cell polarization. It functions in the formation of tight junctions by forming complexes with PARD3 and linking Rho GTPases to atypical protein kinase C proteins, thereby regulating cell polarity processes. The protein localizes to the cytoplasm, cell membrane, and tight junctions, underscoring its role in maintaining cellular structure and function. The provided fragment enables focused investigation into the mechanistic roles of its key domains.
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Protein name
Partitioning defective 6 homolog gamma
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Uniprot ID
Q9BYG4
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Gene Name
PARD6G; PAR6G
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 132-253 aa (Q9BYG4) were fused with 6His tag.
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Sequence
132-253
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 15.01 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 15 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"