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Product Name
Recombinant PAK6 protein (His tag)
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Description
This recombinant protein product features a 298-amino acid fragment (residues 384-681) of human Serine/threonine-protein kinase PAK 6, encompassing its complete protein kinase domain. It serves as an essential tool for investigating kinase activity, androgen receptor regulation, and cytoskeletal dynamics in cellular signaling pathways.
Serine/threonine-protein kinase PAK 6 (PAK6) is a human enzyme that regulates gene transcription through kinase activity induced by effectors including androgen receptor (AR) and MAP2K6. It functions as a transcriptional modulator by phosphorylating AR's DNA-binding domain to inhibit androgen-mediated transcription and similarly suppresses ESR1-mediated transcription. PAK6 contributes to cytoskeleton regulation through IQGAP1 interaction and exhibits anti-apoptotic activity via BAD phosphorylation. The protein localizes to both cytoplasm and nucleus, cotranslocating with AR into the nucleus upon androgen induction, highlighting its role in nuclear signaling processes.
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Protein name
Serine/threonine-protein kinase PAK 6
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Uniprot ID
Q9NQU5
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Gene Name
PAK6; PAK5
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 384-681 aa (Q9NQU5) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 35.60 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 36 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"