Recombinant PAK4 protein (His tag)

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Recombinant Human Serine/threonine-protein kinase PAK 4 (PAK-4) Fragment (aa 298-591) is a high-purity protein encompassing the complete protein kinase domain. This fragment serves as an essential tool for investigating kinase activity, signal transduction pathways, and cytoskeletal regulation in cellular processes.

Serine/threonine-protein kinase PAK 4 is a crucial signaling molecule involved in diverse cellular pathways including cytoskeleton regulation, cell adhesion, migration, proliferation, and survival. It becomes activated through effectors like growth factor receptors, CDC42, and RAC1, leading to autophosphorylation and subsequent phosphorylation of downstream targets such as SSH1, LIMK1, integrin beta5, ARHGEF2, and BAD. These activities modulate cofilin function, actin filament stability, focal adhesion dynamics, and apoptosis. PAK 4 also contributes to cell-cycle progression by regulating CDKN1A and phosphorylating RAN, and promotes focal adhesion disassembly via RHOU stabilization. The protein is primarily localized in the cytoplasm and can translocate to the cell periphery upon activation by signaling pathways.