Recombinant P85B protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) fragment (aa 325-728), encompassing both SH2 domains. This high-purity protein is an essential tool for investigating PI3K signaling mechanisms, domain-specific interactions, and regulatory functions in cell growth, survival, and metabolic pathways.

The full-length Phosphatidylinositol 3-kinase regulatory subunit beta serves as a key regulatory component of phosphoinositide-3-kinase (PI3K), which phosphorylates phosphatidylinositol 4,5-bisphosphate to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 recruits PH domain-containing proteins like AKT1 and PDPK1 to the membrane, activating signaling cascades critical for cell growth, survival, proliferation, motility, and morphology. The protein binds phosphorylated tyrosine kinases via its SH2 domains, acting as an adapter to link the p110 catalytic subunit to the plasma membrane. It also indirectly regulates autophagy and promotes nuclear translocation of XBP1 isoform 2 under ER stress or insulin stimulation, contributing to glucose tolerance improvement.