p63 Rabbit Polyclonal antibody. Positive IF detected in A431 cells. Positive IHC detected in human tonsillitis tissue, human breast hyperplasia tissue, human lung cancer tissue. Positive WB detected in A431 cells, Apoptosised HeLa cells, human heart tissue, mouse heart tissue, U-937 cells. Positive IP detected in A431 cells. Observed molecular weight by Western-blot: 63-68 kDa
ELISA, WB, IHC, IP, IF
Human,Mouse,Rat; other species not tested.
AIS antibody; B(p51A) antibody; B(p51B) antibody; CUSP antibody; EEC3 antibody; KET antibody; LMS antibody; NBP antibody; OFC8 antibody; p40 antibody; p51 antibody; p53CP antibody; p63 antibody; p73H antibody; p73L antibody; RHS antibody; SHFM4 antibody; TP53CP antibody; TP53L antibody; TP63 antibody; TP73L antibody; Tumor protein 63 antibody; tumor protein p63 antibody; Tumor protein p73 like antibody
This antibody was obtained by immunization of p63 recombinant protein (Accession Number: BC039815). Purification method: Antigen affinity purified.
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
A431 cells were subjected to SDS PAGE followed by western blot with Catalog No:113558(TP63 antibody) at dilution of 1:1000
IP Result of anti-TP63 (IP:Catalog No:113558, 4ug; Detection:Catalog No:113558 1:300) with A431 cells lysate 1200ug.
Immunohistochemistry of paraffin-embedded human breast hyperplasia tissue slide using Catalog No:113558(TP63 Antibody) at dilution of 1:200 (under 40x lens)
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:113558(TP63 Antibody) at dilution of 1:200 (under 40x lens)
Immunofluorescent analysis of (10% Formaldehyde) fixed A431 cells using Catalog No:113558(TP63 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
TP63, also named KET, P63, P73H, P73L and TP73L, belongs to the p53 family. It is a homologue of the tumor suppressor p53 and p73 genes. It is involved in malignancy acquisition and maintenance of cells. Unlike p53, the p63 gene encodes multiple isotypes with remarkably divergent abilities to transactivate p53 reporter genes and induce apoptosis. TP63 acts as a sequence specific DNA binding transcriptional activator or repressor. TP63 has 12 isoforms with MW 40kd(P40), 50kd(P60),63kd(P63) and 73kd(P73L). It is Nuclear stain.
- Wang YG, Xie P, Wang YG. All-trans-retinoid acid (ATRA) suppresses chondrogenesis of rat primary hind limb bud mesenchymal cells by downregulating p63 and cartilage-specific molecules. Environmental toxicology and pharmacology. 38(2):460-8. 2014.
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