Recombinant P2RX7 protein (His tag)

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Recombinant Human P2X7 (P2X purinoceptor 7) Fragment (aa 47-328) is a high-purity, soluble protein designed for structural and functional studies. This 282-amino acid fragment, derived from the ATP-gated cation channel P2RX7, offers a stable and biochemically tractable unit ideal for investigating ion channel mechanisms, inflammasome activation, and inflammatory signaling pathways.

P2X7 is a nonselective cation channel activated by high extracellular ATP concentrations, facilitating Na⁺ and Ca²⁺ influx and K⁺ efflux. It plays a critical role in immune responses by triggering NLRP3 inflammasome activation, leading to the release of pro-inflammatory cytokines like IL-1β and IL-18. The receptor also mediates cell death pathways, including apoptosis and autophagy, and is implicated in pathological inflammatory states. Located in the cell membrane as a multi-pass transmembrane protein, P2X7 functions as a key sensor of damage-associated molecular patterns. The provided fragment (aa 47-328) represents a computationally optimized, stable region devoid of transmembrane domains, enabling focused studies on its soluble structural and functional properties.